5-alpha reductase inhibitor

Finasteride

Finasteride is a pill that stops testosterone from turning into dihydrotestosterone (DHT). DHT is the hormone most responsible for male pattern hair loss.

Category: Men's health Used in: Finasteride

How it works

Finasteride blocks an enzyme called type II 5α-reductase. That lowers DHT in the blood and scalp by ~70%. With less DHT, hair follicles shrink more slowly in androgenetic alopecia (pattern hair loss).

The evidence

Long-term trials (1–10 years) of 1 mg daily show more hairs and slower hair loss than placebo. This is especially true at the crown (the top and back of the head). Adding topical minoxidil adds to the effect.

Typical dosing

1 mg by mouth, once a day. Results show up over 3–6 months. To keep the results, you have to keep taking it.

Side effects

Common

  • Lower sex drive
  • Erection changes

Less common

  • Mood changes

Rare

  • Post-finasteride syndrome (debated, still being studied)

Drug interactions

  • Generally few at low doses

Getting it through Zappy

Compounded medicines are made for you by a licensed U.S. pharmacy. They are not FDA-approved, and they are not a generic version of any brand-name drug.

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