Zepbound®, as shipped
Weight loss

Zepbound®

Eli Lilly's FDA-approved tirzepatide for chronic weight management, in the maker's own pen.

See if I qualifyFrom $299/mo

$0 until a clinician approves · FSA/HSA eligible

  • −20.9%Average change in body weight at week 72 on 15 mg
  • FDAApproved for chronic weight management

SURMOUNT-1 · NEJM 2022 · n=2,539

Membership first month $39
Due if approvedpaid to Zappy $39 (then $99/mo)
You'll also pay Eli Lilly for the medication
Zepbound® $299 starting dose then $399–$449/mo
See the price at every dose
2.5 mg starting dose $299/mo
5 mg $399/mo
7.5–15 mg maintenance range $449/mo

These prices need a refill within 45 days of your previous delivery. Otherwise Lilly charges $499 for 7.5 mg and $699 for 10–15 mg.

We send your prescription to LillyDirect, and Eli Lilly bills you directly. Zappy never charges you for the medication, and we don't mark it up.

$0 until a clinician approves.

  • Clinician-reviewed in 24 hours
  • Pause or cancel anytime

To get a prescription, you need an online visit reviewed by a U.S.-licensed provider. Results vary from person to person.

Who it’s for

  • BMI of 27+ with a weight-related health problem, or 30+ without one
  • Tried diet and exercise, but the results didn't last
  • Want less food noise (constant thoughts about food)
See if I qualify

Some days you just want the brand-name pen, in the box it was made for.

What the trials found

Average body-weight change at week 72 (SURMOUNT-1 drug)
Zepbound 15 mg 20.9%
Placebo 3.1%

SURMOUNT-1 · NEJM 2022 · n=2,539 ↗

−20.9%

Average change in body weight at week 72 on 15 mg, in SURMOUNT-1, the trial that tested Zepbound

SURMOUNT-1 · NEJM 2022 · n=2,539 ↗
FDA

Approved for chronic weight management, as brand-name tirzepatide

FDA label
The honest version

These results come from Zepbound, in the brand-name FDA-approved pen. Trial results belong only to the product that was tested. They don't carry over to any other preparation.

What the first months look like

1
Weeks 1–4

Priming dose (2.5 mg).

2
Weeks 5–20

The dose goes up by 2.5 mg about once a month, toward maintenance.

3
Month 5+

Maintenance at 10–15 mg. The week-72 trial results came from these doses.

Dosing, step by step

Ladder 2.5 mg start, +2.5 mg ~monthly to 10–15 mg — as the label sets out

And when it gets rough

Show what helps
  • Nausea It comes from how the drug works and follows your dose steps. It fades as your body adjusts. Pace the steps with your clinician.
  • Injection-site reactions Use a different spot each time. Mild redness right where you inject is normal. Contact your clinician if redness spreads.
Full safety profile →

Safety information

A U.S.-licensed clinician reviews every prescription and decides whether this medicine is right for you. During your visit, tell them if any of the following applies to you or your family.

In rodent studies, semaglutide and tirzepatide caused thyroid C-cell tumors. It is not known whether they cause these tumors, including medullary thyroid carcinoma (MTC), in people. Do not use this medication if you or any of your family have had MTC, or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

Full GLP-1 safety information → See if I qualify
Why we start you here
Zepbound is an FDA-approved form of tirzepatide. It works on two hormone receptors, GIP and GLP-1. That doesn't mean raising the dose will be easier on you. We check whether it's right for you and go over its risks. Dose changes follow the prescribing information, how you respond, and how well you handle it. Tell us about symptoms that bother you before your dose goes up.
Medical Director · Zappy clinical team
How it works

Three steps, no insurance hoops

1

Take the quiz

About 5 minutes. Tell us your symptoms, history, and goals.

2

Clinician reviews

A U.S.-licensed clinician looks at your answers within 24 hours. If it's right for you, they write your plan.

3

Care ships free

Your medication arrives in days. Refills come on their own, and check-ins are included.

What members say

Read all reviews on Trustpilot →
I love Zappy Health!! They started me on my GLP-1 journey in February of 2024!! They helped me when my own doctors wouldn’t! I have exceeded my goal weight and have a healthy BMI of 22!! I started at 49! Thank you Zappy for all you kindness, and your support.. I will be forever grateful
Beth Read on Trustpilot (Beth's review)
At 51 years old, I honestly didn’t think I could turn back the clock the way I have — but this program has helped me in every way possible. I’ve lost a sizable amount of weight but It’s not just about the weight. It’s my energy, my confidence, my discipline, and my mindset. My joints don’t hurt like they used to. I sleep better. I move easier. I feel lighter physically and mentally. And you truly can’t put a price on your health. Their customer service is amazing — I’ve literally received responses within minutes. Any time I’ve had a question or concern, it’s been handled quickly and professionally. This wasn’t overnight. It was consistency. And Zappy gave me the structure to stay consistent. Best investment I’ve made in myself in a long time.
DeAnna Read on Trustpilot (DeAnna's review)
I started with another "Z" company and got more excuses than I cared for... so I tried Zappy. I do my online survey every month to let them know about my weightloss and I've received my injections every month. Flat rate no hidden fees, and the cost doesn't increase. This company is great and helps you every step of the way. Wanna good company to get weightloss prescriptions, go with Zappy.
Nicole Read on Trustpilot (Nicole's review)

Reviews from Trustpilot, published as written. Each reviewer was invited by Trustpilot after a real order. Individual results vary and are not typical.

From some of our members

Real member journeys. The members shown are Zappy affiliates and may receive compensation. Individual results vary and are not typical.

Common questions

How much does Zepbound® cost?
The manufacturer's pharmacy bills you for the medication. It costs $299–$449 a month, depending on the dose. Zappy's care membership is billed separately. It's $39 your first month, then $99/mo. You'll see the full price before checkout. You pay nothing unless a clinician approves you.
How is Zepbound® taken?
You start with a 2.5 mg shot under the skin once a week for 4 weeks. Then the dose goes up every 4 weeks (5 → 7.5 → 10 → 12.5 → 15 mg), as long as your body handles it. The maintenance dose is usually 10–15 mg a week.
What are the side effects of Zepbound®?
Common: nausea, diarrhea, constipation, less appetite, tiredness. Less common: acid reflux, reactions where you inject. Rare: pancreatitis (swelling of the pancreas), gallbladder problems. Your clinician checks your health history before prescribing. They'll change your plan if side effects come up.
Does Zepbound® interact with other medications?
Tell your clinician about everything you take. Known interactions: Insulin and sulfonylureas: higher risk of low blood sugar; Birth control pills: may work less well for a while after each dose increase; Other GLP-1 / GIP medicines: never take them together.
Is Zepbound® FDA-approved?
Yes. Zepbound® is a brand-name, FDA-approved medication, supplied by the manufacturer.

Care that shows up, and stays.

Ready when you are.

A licensed clinician reviews your visit within 24 hours.

See if I qualify · Medication $299–$449/mo