Sermorelin
Sermorelin prompts your pituitary gland to release growth hormone. Evidence that it improves sleep, recovery, or body composition in healthy adults is limited. A clinician oversees every course.
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To get a prescription, you need an online visit reviewed by a U.S.-licensed provider. Compounded medicines are made by licensed U.S. pharmacies and are not FDA-approved. Results vary from person to person.
Who it’s for
- Want an honest talk about what these treatments can and can't do
- Want a clinician involved, instead of gray-market vials
- OK with small shots under the skin (most courses)
Before adding anything new, it's worth finding out what's really going on.
How it works
Sermorelin is a growth-hormone-releasing hormone (GHRH) analog. It signals your pituitary to make its own growth hormone. Some clinicians choose it over HGH because it works with your body's own feedback loop.
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What we can and can't tell you
Evidence that sermorelin improves sleep, recovery, or body composition in healthy adults is limited. A change in growth hormone levels on a blood test doesn't prove it helps your health. We don't promise anti-aging results. Use in adults is off-label, and what we prescribe is compounded, which means it is not FDA-approved.
- Who makes it A LegitScript-verified 503A compounding pharmacy makes it from your prescription. We never use gray-market or overseas suppliers.
- To what standard USP <797> standards for sterile compounding, and USP <800> standards for handling hazardous drugs, where they apply
Compounded medicines are not FDA-approved. The FDA does not review them for safety or effectiveness. They are not generic versions of any brand-name drug, and they are not equivalent to one.
What the first months look like
A shot under the skin before bed, 5 nights a week, timed to the growth hormone (GH) your body naturally releases overnight. Tell your clinician about any reaction.
Your clinician may check IGF-1 (a marker of growth hormone). A change in that number doesn't prove a health benefit.
This is the typical course length. Your clinician reviews how you're doing, any side effects, and whether there's a reason to continue.
Courses are checked again at 3-6 months. Your clinician decides on your dose and whether to keep going, based on how you've responded. It isn't automatic.
Dosing, step by step
| Nightly | 200-500 mcg subcutaneous — before bed, to match your body's natural overnight GH release |
|---|---|
| Frequency | 5 nights per week — not every night, on purpose |
| Course | 3-6 months — with a check-in before you continue |
Your clinician sets the exact dose within the 200-500 mcg range, and how long the course lasts. Taking it before bed matters. The timing is built around your own GH rhythm.
And when it gets rough
Show what helps
- Injection-site reactions Use a different spot each time, and use the right technique. Most reactions are mild and settle down. Tell your clinician about swelling that won't go away or redness that spreads.
- Flushing Usually short-lived after a dose. Tell your clinician if it's strong or lasts.
- Headache or nausea Usually mild. Drinking water and dosing on a steady schedule help. Contact your clinician if it doesn't go away or gets worse.
- Hypersensitivity reaction (rare) Stop and contact your clinician right away if you get a rash, swelling, or trouble breathing. Don't wait to see if it passes.
Safety information
A U.S.-licensed clinician reviews every prescription and decides whether this medicine is right for you. During your visit, tell them if any of the following applies to you or your family.
- Common side effects
- Reactions where you inject, Flushing
- Less common
- Headache, Nausea
- Rare
- Allergic reactions
- Interactions
- Glucocorticoids (steroids like prednisone): may lower the GH response
- Insulin: watch blood sugar, since GH can make your body respond less to insulin
There's only limited evidence that sermorelin improves sleep, recovery, or body shape in healthy adults. A change in growth hormone levels on a blood test doesn't prove it helps your health. We don't promise anti-aging results. Before you start, a clinician looks at what's really bothering you and talks through options with better evidence. They also explain what's still unknown and the risks of the exact product.
Three steps, no insurance hoops
Take the quiz
About 5 minutes. Tell us your symptoms, history, and goals.
Clinician reviews
A U.S.-licensed clinician looks at your answers within 24 hours. If it's right for you, they write your plan.
Care ships free
Your medication arrives in days. Refills come on their own, and check-ins are included.
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Common questions
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A licensed clinician reviews your visit within 24 hours.
See if I qualify · From $159/mo