Weight loss
Compounded and FDA-approved GLP-1s for weight loss. Licensed clinicians adjust your dose. Free delivery and automatic refills.
Guides
A GLP-1 grocery list: what to buy and what to skip
An aisle-by-aisle grocery list for semaglutide or tirzepatide, with USDA protein counts, cheaper ways to buy protein, what to leave on the shelf, and a one-week list for one person.
How sleep affects weight loss on a GLP-1
Short sleep raises hunger hormones and, in one controlled study, shifted weight loss away from fat and toward lean mass. Why semaglutide and tirzepatide can disrupt sleep, and an evening routine that targets those causes.
Do weight loss supplements work?
A few supplements have trial evidence for weight loss, and the best of them average less than a kilogram over placebo. Which ones those are, which are marketing, how to buy safely, and which make sense alongside a GLP-1.
Emotional eating, after GLP-1
A GLP-1 turns down hunger, but it doesn't remove the other reasons you eat. How to name your pattern, and why the time you spend on the drug matters.
Exercise for weight loss: where beginners should start
Exercise on its own takes off a few percent of body weight, and it matters most for keeping weight off and keeping muscle. Where to start if you have joint pain or haven't worked out in years, and how to build up to 150 minutes a week.
How GLP-1 weight loss can change your relationships
Eating less and changing shape on semaglutide or tirzepatide changes how meals, drinks and conversations go with the people around you. Five common situations, what to say in each, and when to bring in a therapist.
Semaglutide, end to end
What semaglutide is, what the evidence shows, how the dose steps really go, and why stopping without a plan usually brings the weight back.
The GLP-1 weight loss guide
What the big studies found for semaglutide and tirzepatide, the heart findings, the muscle caveat, what happens when you stop, and how to choose.
What GLP-1s actually cost
Compounded, branded through the manufacturer, or covered by insurance: three routes with three different bills. How to read each one, and why the honest number is the year.
Eating on a GLP-1 — the whole playbook
Appetite drops fast on semaglutide and tirzepatide, so food quality has to do more work. The protein-first rule, what a slow stomach can't handle, hydration, and alcohol.
The GLP-1 injection guide
Subcutaneous technique, site rotation, missed doses, and storage temperatures for weekly semaglutide and tirzepatide injections, plus when your pharmacy insert overrules any guide.
GLP-1 side effects: the honest map
Almost every GLP-1 side effect comes from one thing: food leaves your stomach more slowly. Here's what's common, what slower dosing fixes, and what needs a clinician the same day.
Stopping a GLP-1: what actually happens
Stop a GLP-1 and your appetite, and much of the lost weight, comes back. What the stopping trials measured, why regain is biology, and how to plan an exit or a lower dose.
Strength and recovery on a weight-loss plan
On a GLP-1, some of what you lose is muscle. The fixes are cheap: enough protein, often 1.2–1.6 g/kg a day, and two strength sessions a week. The evidence, the numbers, and what we still don't know.
Tirzepatide, end to end
A weekly shot that acts on two gut hormones, GLP-1 and GIP. What the evidence shows, how it's dosed, what it feels like, and when to pick it over semaglutide.
Answers
Alcohol on a GLP-1
You can drink, since alcohol and semaglutide don't directly interact. But drinks hit harder on a slow stomach, use up a tight calorie budget, and some people want alcohol less anyway.
Can GLP-1s affect your mood?
In January 2026 the FDA took the suicidal-thoughts warning off the Wegovy and Zepbound labels. Here is what can lower mood early on, what helps, and when to get help the same day.
Compounded semaglutide cost, itemized
At Zappy you pay one flat monthly price that covers your clinician visit, the medication, and shipping. Here's what that buys, what it doesn't (FDA approval), and how it compares to the brand-name pen.
Does biotin help with weight loss?
No good evidence shows that biotin supplements cause weight loss, and high doses can skew lab tests. Why the idea exists, who actually runs low, and what to do about hair shedding on a GLP-1 instead.
Does creatine help with weight loss?
Creatine doesn't burn fat, but taken with resistance training it helps you keep and build muscle while you lose weight. What the scale does in the first weeks, how to take it, and who should check their labs first.
Foods that fight your GLP-1
Fried food, fizzy drinks, and oversized portions clash with a stomach that now empties in slow motion. Here's why, and what to swap in.
GLP-1 and food noise — what changes mentally
The constant thinking about food often quiets down, though how soon varies. It comes from how the drug acts on appetite centers in the brain. Why it happens, when it starts, and what it doesn't fix.
GLP-1 and keto — why you don't need both
Semaglutide and tirzepatide already do what keto is trying to do. Combining them adds side effects with no proven extra weight loss. Here's what to eat instead.
GLP-1 constipation — why it happens and what works
Slower transit, smaller meals, and less fluid make GLP-1 constipation a mechanical problem. Fluids and fiber come first, and your clinician can help you choose a laxative if you need one.
GLP-1 long-term safety — what we know and don't
What we know about GLP-1 safety over several years, what the boxed warning actually says, and what nobody has measured yet.
GLP-1 nausea hacks that actually work
Raising your dose more slowly helps more than any food trick. Here are the fixes for GLP-1 nausea, ranked by evidence, plus the symptoms that aren't nausea at all.
GLP-1s and your gallbladder
Gallstones are a real risk on semaglutide and tirzepatide, but much of it may come from losing weight fast. What the labels flag, and the symptoms that need same-day care.
GLP-1s vs bariatric surgery
Gastric bypass still beats every drug for weight loss. The sleeve and 15 mg tirzepatide now overlap. What the trials and the regain data say, and why a clinician should make the final call.
Headaches and dizziness on a GLP-1
Headaches and lightheadedness on semaglutide or tirzepatide often come from less fluid, salt, and food. The fix, the blood-sugar question, and signs that need same-day care.
Heartburn and reflux on a GLP-1
Semaglutide slows stomach emptying, which drives both the appetite effect and the heartburn. What helps: smaller, earlier meals, raising the bed, sensible antacid use, and spotting a dose signal.
High-protein meals under 10 minutes (GLP-1 edition)
Twelve meals that take 10 minutes or less, with about 20 to 40 g of protein each. Plus the trial data on why muscle is what you're trying to protect.
How long do people stay on GLP-1s?
GLP-1s are long-term medicines, and most people should plan on years. What sets your own timeline, what happens when people stop, and your three options at goal weight.
How long semaglutide and tirzepatide take to work
Appetite often changes in the first week or two. Weight loss builds over months, because it takes about 16 weeks to climb to the full semaglutide dose and about 20 for tirzepatide.
Injection-site reactions — normal vs not
A dime-sized red, itchy bump that fades within a few days is usually normal. Spreading redness, hot skin, or fever is the short list that needs a clinician the same day.
Meal timing and hydration on a GLP-1
Eat bigger meals early, keep dinner small, and sip fluids through the day. Here's why each habit helps on semaglutide or tirzepatide, and which parts come from practice instead of trials.
Missed your dose? Here's the rule
Each GLP-1 label has its own missed-dose rule: Ozempic, Wegovy, and Zepbound all say it differently. Why doubling up always backfires, and when a gap is a question for your clinician.
Oral vs injectable GLP-1s
The weekly shot is backed by trials of nearly 20,000 patients. How the daily semaglutide pills compare, what each is approved for, and how to choose.
Paying for GLP-1s with FSA/HSA
Prescription GLP-1s count as qualified medical expenses when they treat a diagnosed condition. What the pre-tax discount is worth, which receipt to keep, and what your account won't cover.
Protein targets on a GLP-1: the numbers
A common range is 1.2–1.6 g of protein per kilogram of body weight per day, and your clinician sets your own target. Here's what that range means in grams at your weight, and how to eat it when your appetite is gone.
Rebound weight after stopping: the data
A large share of GLP-1 weight loss comes back within a year of stopping. Here's what the stopping trials measured, and why the rebound comes from biology instead of willpower.
Semaglutide not working? Run this checklist
How to tell impatience from a true non-response (dose, missed shots, appetite), and when switching to tirzepatide makes sense.
Switching from semaglutide to tirzepatide
You can, with a clinician's help. There's no proven dose conversion chart, so you restart tirzepatide low and work up. Who switches, how the changeover works, and why month one can feel like a step back.
The first four weeks on a GLP-1
What really happens on the 0.25 mg starter dose: appetite often eases early, side effects often ease, and the scale may stay quiet at first.
The maintenance-dose option
No trial has tested whether a lower semaglutide dose can hold the weight you lost on the full dose. Here's what the stopping trials show, how a step-down works, and what each choice costs.
Tracking GLP-1 progress beyond the scale
While your dose is still going up, the scale mostly tracks your dose schedule. Weigh weekly, measure your waist weekly, test grip monthly, and use week 12 as a check-in with your clinician.
Traveling with a GLP-1
Semaglutide and tirzepatide travel fine once you know how long your product can stay out of the fridge. Carry-on rules, the parked-car risk, and who to call if a dose got warm.
What to do about a GLP-1 weight loss plateau
When the scale stops on a GLP-1, the medicine usually hasn't quit. Here's the six-week test, the dose check, and the one move that reliably backfires.
Where to inject — sites and rotation
Abdomen, front of the thigh, or back of the upper arm: these are the three standard sites. What matters is moving the exact spot each week, with a rotation pattern that takes no memory.
Who qualifies for a GLP-1 — the BMI math
A BMI of 30 qualifies on its own, and 27 does with one weight-related condition. Where the cutoffs come from, what counts as a comorbidity, and why a clinician makes the final call.
Will insurance cover a GLP-1 for weight loss?
By law, regular Medicare can't cover weight-loss drugs, with one temporary exception, and commercial plans often exclude GLP-1s or require prior authorization. The honest picture, and five questions that get a straight answer.