Weight loss

Semaglutide

A weekly GLP-1 shot that quiets food noise and steadies blood sugar. A licensed U.S. pharmacy makes it for you, and a clinician raises your dose slowly.

See if I qualifyFrom $159/mo

$0 until a clinician approves · FSA/HSA eligible

$0 until a clinician approves.

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To get a prescription, you need an online visit reviewed by a U.S.-licensed provider. Compounded medicines are made by licensed U.S. pharmacies and are not FDA-approved. Results vary from person to person.

Who it’s for

BMI of 27+ with a weight-related health problem, or 30+ without one
Tried diet and exercise, but the results didn't last
Want less food noise (constant thoughts about food)

See if I qualify

Most people notice they're less hungry before the scale moves.

How it works

Semaglutide is a once-weekly GLP-1 medicine. It slows how fast your stomach empties, helps your body use insulin better, and makes you less hungry.

Read the full Semaglutide profile →

What we can and can't tell you

Results are different for everyone. The weight loss only lasts while you stay on treatment. Most people gain weight back after stopping if they don't have a plan to keep it off.

Who makes it A LegitScript-verified 503A compounding pharmacy makes it from your prescription. We never use gray-market or overseas suppliers.
To what standard USP <797> standards for sterile compounding, and USP <800> standards for handling hazardous drugs, where they apply

How we source and ship →

Compounded medicines are not FDA-approved. The FDA does not review them for safety or effectiveness. They are not generic versions of any brand-name drug, and they are not equivalent to one.

What the first months look like

Weeks 1–4

Starter dose (0.25 mg). You'll feel less hungry first. The scale stays put for now, and that's expected.

Weeks 4–16

Your dose goes up about every 4 weeks. Side effects tend to show up after each step. Then they fade as your gut gets used to it.

Month 4+

Maintenance dose (the dose you stay on). This is when the real change builds. It happens over months, well past the first few weeks.

Ongoing

Check-ins, small dose changes, and a real plan before you ever stop. If weight comes back after stopping, that's your body's biology. It doesn't mean you failed.

Dosing, step by step

Start	0.25 mg weekly — a low dose so your stomach can adjust; it isn't for weight loss yet
Step 2	0.5 mg weekly — ~week 5
Step 3	1.0 mg weekly — ~week 9
Step 4	1.7 mg weekly — ~week 13
Target	2.4 mg weekly — most members stay between 1.0–2.4 mg

Your clinician sets the pace. Staying on a step longer because of side effects is normal.

And when it gets rough

Show what helps

Nausea Eat smaller meals, eat slowly, and go easy on fat. Nausea tends to follow dose steps, then fades. If you keep throwing up, contact your clinician the same day.
Constipation Drink more fluids first. Then add fiber, then magnesium. Check with your clinician if you need more help.
Fatigue (early) Usually it's about what you take in. Drink enough water, get your electrolytes (salts like sodium and potassium), and eat your daily minimum of protein.
Reflux Eat a smaller dinner, earlier. Raise the head of your bed. Tell your clinician if reflux is new or getting worse.

Full safety profile →

Safety information

A U.S.-licensed clinician reviews every prescription and decides whether this medicine is right for you. During your visit, tell them if any of the following applies to you or your family.

In rodent studies, semaglutide and tirzepatide caused thyroid C-cell tumors. It is not known whether they cause these tumors, including medullary thyroid carcinoma (MTC), in people. Do not use this medication if you or any of your family have had MTC, or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

Full GLP-1 safety information → See if I qualify

Why we start you here

Before choosing a weight plan, we go over your health history, your goals, and your options. Compounded medicines are not FDA-approved. The FDA hasn't reviewed them for safety, effectiveness, or quality. Results from trials of brand-name drugs don't prove the same results for a compounded version. Brand-name options are FDA-approved, and you can ask us how they compare for you.

Medical Director · Zappy clinical team

How it works

Three steps, no insurance hoops

Take the quiz

About 5 minutes. Tell us your symptoms, history, and goals.

Clinician reviews

A U.S.-licensed clinician looks at your answers within 24 hours. If it's right for you, they write your plan.

Care ships free

Your medication arrives in days. Refills come on their own, and check-ins are included.

Comparing options?

Semaglutide vs Tirzepatide → Compounded vs Branded →

What members say

Read all reviews on Trustpilot →

I love Zappy Health!! They started me on my GLP-1 journey in February of 2024!! They helped me when my own doctors wouldn’t! I have exceeded my goal weight and have a healthy BMI of 22!! I started at 49! Thank you Zappy for all you kindness, and your support.. I will be forever grateful

Beth Read on Trustpilot

At 51 years old, I honestly didn’t think I could turn back the clock the way I have — but this program has helped me in every way possible. I’ve lost a sizable amount of weight but It’s not just about the weight. It’s my energy, my confidence, my discipline, and my mindset. My joints don’t hurt like they used to. I sleep better. I move easier. I feel lighter physically and mentally. And you truly can’t put a price on your health. Their customer service is amazing — I’ve literally received responses within minutes. Any time I’ve had a question or concern, it’s been handled quickly and professionally. This wasn’t overnight. It was consistency. And Zappy gave me the structure to stay consistent. Best investment I’ve made in myself in a long time.

DeAnna Read on Trustpilot

I started with another "Z" company and got more excuses than I cared for... so I tried Zappy. I do my online survey every month to let them know about my weightloss and I've received my injections every month. Flat rate no hidden fees, and the cost doesn't increase. This company is great and helps you every step of the way. Wanna good company to get weightloss prescriptions, go with Zappy.

Nicole Read on Trustpilot

Reviews from Trustpilot, published as written. Each reviewer was invited by Trustpilot after a real order. Individual results vary and are not typical.

From some of our members

Real member journeys. The members shown are Zappy affiliates and may receive compensation. Individual results vary and are not typical.

Common questions

How much does Semaglutide cost?

From $159/mo on a 6‑month plan, or $199 if you pay month to month. That price covers everything: the medication and your clinician's care. There's no membership fee, and the price is the same at every dose. You'll see the full price before checkout. You pay nothing unless a clinician approves you.

How is Semaglutide taken?

The dose goes up slowly. This is called titration. You start with a 0.25 mg shot under the skin once a week for 4 weeks. Then the dose steps up every 4 weeks (0.5 → 1.0 → 1.7 → 2.4 mg), as long as your body handles it. The maintenance dose is usually between 1.0 mg and 2.4 mg a week.

What are the side effects of Semaglutide?

Common: nausea, constipation, diarrhea, tiredness (early on, while the dose goes up), less appetite. Less common: acid reflux, reactions where you inject, gallbladder discomfort. Rare: pancreatitis (swelling of the pancreas), sudden kidney injury (linked to dehydration). Your clinician checks your health history before prescribing. They'll change your plan if side effects come up.

Does Semaglutide interact with other medications?

Tell your clinician about everything you take. Known interactions: Insulin and sulfonylureas: higher risk of low blood sugar. Their doses may need to be lowered; Pills that need very exact dosing (a narrow therapeutic window): absorbed more slowly, because your stomach empties more slowly; GLP-1 / GIP medicines like tirzepatide: never take them together.

Is Semaglutide FDA-approved?

No. Compounded medicines are made for you by licensed U.S. pharmacies, based on your prescription. They are not FDA-approved.

What is compounded semaglutide?

It's semaglutide made just for you by a LegitScript-verified 503A pharmacy. The pharmacy follows your prescription, and your clinician oversees your care. Compounded medicines are not FDA-approved.

How is it dosed?

It's a shot under the skin once a week. Most members start at 0.25 mg. The dose goes up slowly over about 16 weeks.

Do I need insurance to start?

No. Zappy is cash-pay. You can use an FSA or HSA card for eligible costs.