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Weight loss

Tirzepatide

A weekly shot that acts on two hormones, GLP-1 and GIP. A licensed U.S. pharmacy makes it for you, and a clinician raises your dose slowly.

See if I qualifyFrom $279/mo

$0 until a clinician approves · FSA/HSA eligible

$0 until a clinician approves.

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To get a prescription, you need an online visit reviewed by a U.S.-licensed provider. Compounded medicines are made by licensed U.S. pharmacies and are not FDA-approved. Results vary from person to person.

Who it’s for

BMI of 27+ with a weight-related health problem, or 30+ without one
Tried diet and exercise, but the results didn't last
Want less food noise (constant thoughts about food)

See if I qualify

It works on two hormones, and the dose climbs slowly.

How it works

Tirzepatide is a weekly shot that acts on two hormones, GLP-1 and GIP. The GIP part appears to add weight loss and make high doses easier to handle.

Read the full Tirzepatide profile →

What we can and can't tell you

We don't yet know whether this medicine protects the heart over the long term. If that matters most to you, talk it through with your clinician before you choose.

Who makes it A LegitScript-verified 503A compounding pharmacy makes it from your prescription. We never use gray-market or overseas suppliers.
To what standard USP <797> standards for sterile compounding, and USP <800> standards for handling hazardous drugs, where they apply

How we source and ship →

Compounded medicines are not FDA-approved. The FDA does not review them for safety or effectiveness. They are not generic versions of any brand-name drug, and they are not equivalent to one.

What the first months look like

Weeks 1–4

Priming dose (2.5 mg). This is not a treatment dose. It's there to help your stomach get used to the medicine.

Weeks 5–20

Your dose goes up in 2.5 mg steps about every 4 weeks. Side effects tend to show up after each step. How fast you step up is the main thing you can change.

Month 5+

Maintenance at 10–15 mg. This is when the change builds, over months.

Ongoing

Check-ins and dose changes. Weight tends to come back after stopping. So if you stop, we plan it and lower the dose slowly.

Dosing, step by step

Start	2.5 mg weekly — priming dose, 4 weeks
Steps	+2.5 mg ~every 4 weeks — 5 → 7.5 → 10 → 12.5 mg as tolerated
Target	10–15 mg weekly — your clinician weighs any step above 10 mg against side effects

Your clinician sets the pace. Going slower is common and medically fine.

And when it gets rough

Show what helps

Nausea It happens for the same reason as with all GLP-1s. Eat smaller, low-fat meals and step up more slowly. Tell your clinician if it gets worse instead of fading.
Constipation Try fluids, then fiber, then magnesium, in that order. Work with your clinician.
Early fullness Work with it. Eat your protein first, and stop when you first feel full.
Injection-site redness Use a different spot each week. Mild redness where you inject is common and goes away soon.

Full safety profile →

Safety information

A U.S.-licensed clinician reviews every prescription and decides whether this medicine is right for you. During your visit, tell them if any of the following applies to you or your family.

In rodent studies, semaglutide and tirzepatide caused thyroid C-cell tumors. It is not known whether they cause these tumors, including medullary thyroid carcinoma (MTC), in people. Do not use this medication if you or any of your family have had MTC, or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

Full GLP-1 safety information → See if I qualify

Why we start you here

The right weight treatment depends on your health history, goals, how you respond, and how well you handle it. A plateau doesn't automatically mean you need to switch or raise your dose. Compounded tirzepatide is not FDA-approved. Results from brand-name trials don't prove it works the same way or as well. Brand-name options are FDA-approved, and you can ask us how they compare for you.

Medical Director · Zappy clinical team

How it works

Three steps, no insurance hoops

Take the quiz

About 5 minutes. Tell us your symptoms, history, and goals.

Clinician reviews

A U.S.-licensed clinician looks at your answers within 24 hours. If it's right for you, they write your plan.

Care ships free

Your medication arrives in days. Refills come on their own, and check-ins are included.

Comparing options?

Semaglutide vs Tirzepatide → Wegovy vs Zepbound →

What members say

Read all reviews on Trustpilot →

I love Zappy Health!! They started me on my GLP-1 journey in February of 2024!! They helped me when my own doctors wouldn’t! I have exceeded my goal weight and have a healthy BMI of 22!! I started at 49! Thank you Zappy for all you kindness, and your support.. I will be forever grateful

Beth Read on Trustpilot

At 51 years old, I honestly didn’t think I could turn back the clock the way I have — but this program has helped me in every way possible. I’ve lost a sizable amount of weight but It’s not just about the weight. It’s my energy, my confidence, my discipline, and my mindset. My joints don’t hurt like they used to. I sleep better. I move easier. I feel lighter physically and mentally. And you truly can’t put a price on your health. Their customer service is amazing — I’ve literally received responses within minutes. Any time I’ve had a question or concern, it’s been handled quickly and professionally. This wasn’t overnight. It was consistency. And Zappy gave me the structure to stay consistent. Best investment I’ve made in myself in a long time.

DeAnna Read on Trustpilot

I started with another "Z" company and got more excuses than I cared for... so I tried Zappy. I do my online survey every month to let them know about my weightloss and I've received my injections every month. Flat rate no hidden fees, and the cost doesn't increase. This company is great and helps you every step of the way. Wanna good company to get weightloss prescriptions, go with Zappy.

Nicole Read on Trustpilot

Reviews from Trustpilot, published as written. Each reviewer was invited by Trustpilot after a real order. Individual results vary and are not typical.

From some of our members

Real member journeys. The members shown are Zappy affiliates and may receive compensation. Individual results vary and are not typical.

Common questions

How much does Tirzepatide cost?

From $279/mo on a 6‑month plan, or $349 if you pay month to month. That price covers everything: the medication and your clinician's care. There's no membership fee, and the price is the same at every dose. You'll see the full price before checkout. You pay nothing unless a clinician approves you.

How is Tirzepatide taken?

You start with a 2.5 mg shot under the skin once a week for 4 weeks. Then the dose goes up every 4 weeks (5 → 7.5 → 10 → 12.5 → 15 mg), as long as your body handles it. The maintenance dose is usually 10–15 mg a week.

What are the side effects of Tirzepatide?

Common: nausea, diarrhea, constipation, less appetite, tiredness. Less common: acid reflux, reactions where you inject. Rare: pancreatitis (swelling of the pancreas), gallbladder problems. Your clinician checks your health history before prescribing. They'll change your plan if side effects come up.

Does Tirzepatide interact with other medications?

Tell your clinician about everything you take. Known interactions: Insulin and sulfonylureas: higher risk of low blood sugar; Birth control pills: may work less well for a while after each dose increase; Other GLP-1 / GIP medicines: never take them together.

Is Tirzepatide FDA-approved?

No. Compounded medicines are made for you by licensed U.S. pharmacies, based on your prescription. They are not FDA-approved.

Why does it act on both GLP-1 and GIP?

GIP is a second gut hormone. It works alongside GLP-1 to help your body respond to insulin.

Do I need insurance to start?

No. Zappy is cash-pay. You can use an FSA or HSA card for eligible costs.

How fast will I see results?

Most members feel less hungry within 1–2 weeks. Weight usually starts to change around week 4–8, as your dose slowly goes up.